Inhibition of the Ca2+/Calmodulin-dependent Protein Kinase I Cascade by cAMP-dependent Protein Kinase
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چکیده
منابع مشابه
THE EFFECT OF THEOPHYLLINE ON THE KINETICS OF cAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT, cAMP, PROTEIN KINASE INHIBITOR AND THEIR RELATIONSHIP IN LUNG TISSUE
We have investigated the effect of theophylline on the kinetics of the catalytic subunit of protein kinase and related factors in lung tissue. The results show that the point of highest concentration of the C subunit of protein kinase which is active in casein phosphorylation is at 3h of incubation time, but in the presence of 100 Ilg/ InL and 10µg/mL theophylline, this is shifted to I.S an...
متن کاملthe effect of theophylline on the kinetics of camp-dependent protein kinase catalytic subunit, camp, protein kinase inhibitor and their relationship in lung tissue
we have investigated the effect of theophylline on the kinetics of the catalytic subunit of protein kinase and related factors in lung tissue. the results show that the point of highest concentration of the c subunit of protein kinase which is active in casein phosphorylation is at 3h of incubation time, but in the presence of 100 ilg/ inl and 10µg/ml theophylline, this is shifted to i.s and 2....
متن کاملPhosphorylation and activation of cAMP-dependent protein kinase by phosphoinositide-dependent protein kinase.
Although phosphorylation of Thr-197 in the activation loop of the catalytic subunit of cAMP-dependent protein kinase (PKA) is an essential step for its proper biological function, the kinase responsible for this reaction in vivo has remained elusive. Using nonphosphorylated recombinant catalytic subunit as a substrate, we have shown that the phosphoinositide-dependent protein kinase, PDK1, expr...
متن کاملInhibition by calmodulin of the cAMP-dependent protein kinase activation of phosphorylase kinase.
Calmodulin is shown to inhibit both the activation and phosphorylation of phosphorylase kinase by cAMP-dependent protein kinase. Maximal inhibition of both processes was approximately 66% at the highest calmodulin concentration tested (5.5 microM). It was found that the inhibition of phosphorylation was calcium-dependent, reversible by trifluoperazine, and specific for the beta subunit of phosp...
متن کاملDynamics of cAMP-dependent protein kinase.
B. N-Terminus/C-Terminus 2253 1. N-Terminal Tail 2253 2. C-Terminal Tail 2257 C. Signal Integration Motifs 2257 1. C Helix 2258 2. Activation Loop 2258 3. F Helix 2258 D. Dynamics 2259 1. Fluorescence Anisotropy 2259 2. Molecular Dynamic Simulations 2260 III. Inhibitors of the Catalytic Subunit 2260 A. Protein Kinase Inhibitor 2260 B. Regulatory Subunits 2262 1. cAMP-Binding Domains 2263 2. Ove...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1999
ISSN: 0021-9258
DOI: 10.1074/jbc.274.15.10086